Molecular Diagnostics at Home
Lucira Health (acquired by Pfizer)

Molecular Diagnostics at Home

Developed the world's first home-use molecular diagnostic platform capable of detecting COVID-19 and other respiratory pathogens with lab-quality accuracy.

Technologies Used:

Microfluidics Molecular Diagnostics Consumer Health Mobile App Integration

Key Achievements:

  • First FDA-authorized home molecular test for COVID-19
  • 30-minute test-to-result time
  • 95%+ accuracy compared to lab-based PCR
  • Rapidly scaled production to ~1M units/month
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Universal Microfluidic Automation
Mosaic Design Labs (Internal R&D)

Universal Microfluidic Automation

Building the AI-driven laboratory of the future with a programmable microfluidic platform that brings single-cell precision and real-time intelligence to biological research and drug discovery.

Technologies Used:

Microfluidics AI/ML Lab Automation Live Cell Imaging Advanced Manufacturing

Key Achievements:

  • Programmable workflows at single-cell resolution
  • AI-driven experimental design and analysis
  • Seamless integration with traditional automation
  • Initial applications: organoid perfusion & microbiology
  • Open architecture for collaborative science
Foodborne Pathogen Test System
Spectacular Labs

Foodborne Pathogen Test System

Developed a fully functional proof-of-concept instrument and cartridge system for rapid detection of foodborne pathogens.

Technologies Used:

Microfluidics Mechatronics Thermal Engineering Optical Detection

Key Achievements:

  • Cartridge with integrated syringe and valve mechanism
  • Instrument with multi-zone heating & stepper actuation
  • Python interface for testing & plotting
  • Touchscreen UI
AI-Powered 3D Vision System
Tangram Vision

AI-Powered 3D Vision System

Developed a next-generation 3D imaging device combining stereo vision, structured light, and edge AI for industrial robotics and autonomous vehicles.

Technologies Used:

Computer Vision Edge AI Embedded Linux Optical Engineering Thermal Management

Key Achievements:

  • Ultra-compact 14-layer PCBA with TI TDA4VM SoC
  • Fanless thermal management
  • 15W power budget (USB-C or PoE)
  • Custom Yocto Linux with kernel drivers
Real-Time Colorimetric Assay Instrument
Pfizer

Real-Time Colorimetric Assay Instrument

Developed a high-throughput, automation-ready instrument for real-time monitoring of colorimetric LAMP assays

Technologies Used:

Lab Automation Thermal Control Embedded Linux Cloud Integration

Key Achievements:

  • 48-well multiplexed real-time monitoring
  • ±0.1°C temperature uniformity across all wells
  • Fleet management with OTA updates
  • Cloud-based data aggregation and QC analytics
Imaging Bathroom Scale
Empo Health

Imaging Bathroom Scale

Developed a proof-of-concept prototype for a revolutionary imaging bathroom scale designed to assist diabetic patients.

Technologies Used:

Rapid Prototyping Sensor Integration Optical Simulation Ray Tracing Clinical Validation

Key Achievements:

  • Delivered functional prototype in under 8 weeks
  • Integrated imaging sensor into low-profile form factor
  • Enabled clinical proof-of-concept validation study
  • Creative off-the-shelf component integration
"Frankie and his team understood our needs and were able to think outside the box and quickly put together a solution we could use in the clinic. We really appreciated Mosaic's communication and creative problem solving throughout the project."
— Eric Dahlseng, Empo Health
Organoid Differentiation Kit
Bullseye Biotechnologies

Organoid Differentiation Kit

Developed automated liquid handling protocols for manufacturing vascularized cardiac organoid differentiation kits and patterning plates.

Technologies Used:

Liquid Handling Automation OPENTRONS OT-2 Stem Cell Culture Kit Manufacturing Protocol Development

Key Achievements:

  • Automated reagent production protocol on Opentrons OT-2
  • Developed plate spotting workflow for multi-well plates
  • Designed kit packaging for commercial distribution
  • Distributed test kits to academic partners
Point-of-Care Cardiac Panel
XCellCure

Point-of-Care Cardiac Panel

Developed a microfluidic consumable and point-of-care reader instrument capable of quantifying a cardiac protein biomarker panel.

Technologies Used:

Protein Microarrays Optical Engineering Image Analysis Microfluidics Point-of-Care Diagnostics

Key Achievements:

  • 13-biomarker multiplexed panel
  • Results in under 30 minutes
  • Embedded microscope imaging system
  • Automated image analysis and quantification
  • Cloud connectivity for data management
iPhone Ophthalmoscope
UC Berkeley CellScope

iPhone Ophthalmoscope

Developed a smartphone-based ophthalmoscope for diagnostic-quality, widefield retinal imaging in resource-poor settings, achieving performance comparable to clinical fundus cameras.

Technologies Used:

Mobile Health Optical Engineering BLE Hardware Image Stitching iOS Development

Key Achievements:

  • Diagnostic-quality retinal imaging on iPhone
  • Widefield imaging via automated stitching
  • Programmable fixation display system
  • Published in peer-reviewed journals

Other Projects

In addition to our featured case studies, Mosaic has developed solutions across a wide range of applications:

Automated TB Diagnostics

Automated TB Diagnostics

Developed automated fluorescent slide scanning microscope based around an iPad with AI image classification algorithms for detecting tuberculosis. Piloted devices in Vietnam.

Electrophysiological Cell Sorting

Electrophysiological Cell Sorting

Engineered a microfluidic platform for sorting cells based on electrical properties, enabling label-free cell separation for research and diagnostic applications.

Bovine Methane Sensor

Bovine Methane Sensor

Created portable sensor systems for real-time monitoring of methane and CO2 emissions in livestock, supporting agricultural sustainability and environmental research.

Spinal Cord Stimulator Modeling

Spinal Cord Stimulator Modeling

Conducted finite element analysis to optimize electrode placement and electrical field distribution for neuromodulation devices, improving therapeutic outcomes.

Automated Functional Test Fixtures

Automated Functional Test Fixtures

Designed custom test fixtures and automation systems for manufacturing quality control, reducing test time and improving reliability across various product lines.

Microfluidic Cellular "Jungle Gyms"

Microfluidic Cellular "Jungle Gyms"

Developed microfluidic devices for studying bacterial and cellular motility at single-cell resolution, enabling fundamental research in microbiology and cell biology.

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